Harmony analyzes DNA

During pregnancy, the mother’s blood contains fragments of the developing baby’s DNA. Harmony is a new type of test that analyzes this DNA in a blood sample to predict the probability of trisomy 21 (Down syndrome), as well as trisomies 18 and 13, in the baby.

A targeted approach

While traditional blood tests (first trimester screening = KUB) can miss as many as 15% of Down syndrome cases in pregnant women2, Harmony’s DNA-based technology accurately identifies more than 99% of cases.1

The Harmony Prenatal Test specifically targets the DNA in chromosomes 21, 18 and 13. While rare, these are the most common trisomies that occur in babies born to women of any age, when no other risk factors are known.4

The Harmony Prenatal Test  also offers the possibility to analyse fetal gender, sex chromosomal aneuploidies and the most frequently occurring chromosomal deletion, 22q11.2.

Learn more about 22q11.3 deletion syndrome

Learn more about chromosomal syndromes

Superior quality control

The Harmony Prenatal Test incorporates extensive quality controls. These controls include measurement of the amount of the developing baby’s DNA in each sample, to ensure that there is enough DNA present to return a reliable result.3 While it may seem surprising, not all DNA-based genetic tests take the care to measure this basic information.
Harmony Microarray-based performance

  1. Norton et al. N Engl J Med. 2015 Apr 23;372(17):1589-97
  2. ACOG Practice Bulletin 77. ACOG Committee on Practice Bulletins. Obstet Gynecol. 2007 Jan;109(1):217-27
  3. Sparks et al. Am J Obstet Gynecol. 2012 Apr;206(4):319.e1-9.
  4. Grati FR et al. Am J Med Genet Part A 152A:1434–1442.